| Pair Name | Capsaicin, Cisplatin | ||
| Phytochemical Name | Capsaicin (PubChem CID: 1548943 ) | ||
| Anticancer drug Name | Cisplatin (PubChem CID: 5702198 ) | ||
| Structure of Phytochemical |
|
Download
2D
MOL
3D
MOL
|
|
| Structure of Anticancer Drug |
|
Download
2D
MOL
3D
MOL
|
|
| Pair Name | Capsaicin, Cisplatin | |||
| Disease Info | [ICD-11: 2B72] | Gastric cancer | Investigative | |
| Biological Phenomena | Induction-->Blockade of cell cycle in G1/S phase | |||
| Gene Regulation | Down-regulation | Expression | AURKB | hsa9212 |
| Down-regulation | Phosphorylation | NFKBIA | hsa4792 | |
| In Vitro Model | SNU-1 | Gastric adenocarcinoma | Homo sapiens (Human) | CVCL_0099 |
| SNU-5 | Gastric adenocarcinoma | Homo sapiens (Human) | CVCL_0078 | |
| SNU-16 | Gastric adenocarcinoma | Homo sapiens (Human) | CVCL_0076 | |
| SNU-601 | Gastric signet ring cell adenocarcinoma | Homo sapiens (Human) | CVCL_0101 | |
| SNU-638 | Gastric adenocarcinoma | Homo sapiens (Human) | CVCL_0102 | |
| SNU-668 | Gastric signet ring cell adenocarcinoma | Homo sapiens (Human) | CVCL_5081 | |
| Result | Capsaicin induces apoptosis of cisplatin-resistant stomach cancer cells by causing degradation of cisplatin-inducible Aurora-A protein | |||
| No. | Title | Href |
|---|---|---|
| 1 | Capsaicin induces apoptosis of cisplatin-resistant stomach cancer cells by causing degradation of cisplatin-inducible Aurora-A protein. Nutr Cancer. 2011;63(7):1095-1103. doi:10.1080/01635581.2011.607548. | Click |
